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KMID : 0387420130240030271
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Korean Society of Oriental Neuropsychiatry
2013 Volume.24 No. 3 p.271 ~ p.280
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The Involvement of AMPA Receptor in the Antidepressant-like Effects of the Portulaca Oleracea L. Extract in Mice
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Park Soo-Jin
Choi Min-Ji
Chung Sun-Yong
Kim Jong-Woo
Cho Seung-Hun
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Abstract
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Objectives: The development of natural drugs with antidepressant effects is important and needed. This study was performed to investigate the antidepressant-like effects of the distilled water extract of Portulaca oleracea L. (POL) in a mouse model and to investigate the role of ${\alpha}$ 수식 이미지-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects.
Methods: The forced swim test (FST) and tail suspension test (TST) were used to investigate the behavioral anti-depressive-like effects of POL in mice. Additional behavioral experiments with 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione, an AMPA receptor antagonist, were undertaken to determine the involvement of the antidepressant-like properties of POL in AMPA receptor throughput.
Results: Oral administration of the POL extract (100 mg/kg) 1 h prior to testing significantly reduced the immobility times in the FST and TST. The antidepressant-like effects of the POL extract were not increased in a dose-dependent manner. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the POL extract in the FST.
Conclusions: The distilled water extract of POL has antidepressant-like effects, which may be related to AMPA receptor. Pre-treatment with NBQX significantly attenuates the reduction in immobility time induced by the POL extract in the FST.
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KEYWORD
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Antidepressant, Portulaca oleracea L. (POL), Forced swim test (FST), Tail suspension test (TST), Depression, ${\alpha}$ 수식 이미지-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)
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